Melanoma · Pancreas · Pathology
NCI Genomic Data Commons — TCGA
Explore clinical, molecular and tissue-slide data, including melanoma (TCGA-SKCM) and pancreatic adenocarcinoma (TCGA-PAAD).
Open and controlled accessExplore datasetResources
Good science.
Shared openly.
Datasets to explore, methods to reuse and papers that open up new ways of thinking.
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Public datasets.
A starting collection for pathology, spatial biology and cancer research. Check each provider’s access terms and citation guidance.
Melanoma · Imaging
TCIA — Cancer Moonshot Biobank Melanoma
De-identified melanoma histopathology and radiology with supporting clinical information.
Public collectionExplore datasetSpatial biology · Multi-omics
Human Tumor Atlas Network
Multimodal cancer atlases connecting tissue imaging, spatial measurements and molecular profiles.
Access varies by datasetExplore datasetPancreas · Spatial biology
10x Genomics — pancreatic cancer Xenium
Spatial-expression data for exploring transcripts, cell segmentation and the organisation of pancreatic cancer tissue.
Public demonstration datasetExplore datasetSingle-cell · Reference data
CZ CELLxGENE Discover
Search and explore single-cell datasets for cell-type annotation and reference comparisons.
Public portalExplore datasetFrom our lab
Data behind the work.
Published supporting data and methods are linked through the relevant papers. For additional lab datasets, annotations or analysis materials, contact us to discuss availability and the conditions for access.
Access to patient-derived data may depend on consent, ethics approval and a data-sharing agreement.
Methods you can build on
Protocols & workflows.
Published approaches connected to our research.
Multiplex chromogenic immunohistochemistry
A sequential staining and image-analysis workflow for multiplex brightfield imaging of paraffin tissue sections.
Read the protocolECM organisation & mechanical memory
Published methods and supporting materials for analysing matrix organisation, invasion and mechanical memory.
Methods & source dataA preclinical migrastatics pipeline
An integrated workflow combining public-data analysis, invasion assays and preclinical tracking of melanoma metastasis.
Explore the workflowSelected reading
Paper hall of fame.
Foundational papers, useful methods and big ideas. A growing reading list across four themes.
8 papers
EMT & plasticity
Guidelines and definitions for research on epithelial–mesenchymal transition
A shared framework for describing EMT, phenotypic plasticity and intermediate cell states.
EMT & plasticity
Identification of the tumour transition states occurring during EMT
Experimental evidence for distinct intermediate EMT states with different biological properties.
Computational pathology & deep learning
Clinical-grade computational pathology using weakly supervised deep learning on whole slide images
How slide-level labels can train pathology models without exhaustive regional annotations.
Computational pathology & deep learning
Data-efficient and weakly supervised computational pathology on whole-slide images
CLAM connects whole-slide classification with interpretable attention maps.
Spatial biology
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics
A foundational approach for connecting gene expression with tissue organisation.
Spatial biology
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front
Multiplex imaging reveals how cellular neighbourhoods relate to tumour immunity.
3D models
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
A foundational demonstration of self-organising intestinal organoids grown from single stem cells.
3D models
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Pancreatic organoids as models of normal tissue, cancer progression and therapeutic opportunities.
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